The sequencing of the entire genomes of P. falciparum genome (Nature. 2002 Oct 3;419: 6906) and An. gambiae genome (Science. 2002 Oct 4;298:5591 ) in addition to that of humans (Science 2001 Feb 16; 291:5507), enables new research approaches in the fight against malaria. This reveals a unique opportunity to take use of both host systems to investigate how this specialized parasite has adapted to the immune responses that it is destined to encounter.