One of these factors is NhhA (Neisseria his/hsf homologue) and it was shown that NhhA is important for bacterial attachment to epithelial cells (Sjölinder et al. Infect Immun 2008). Furthermore, the recombinant protein is able to induce bactericidal antibodies and hence has also been considered as a potential vaccine candidate. Direct binding between NhhA and the extracellular matrix protein laminin and between NhhA and heparan sulphate has been demonstrated. The goal of this project will be to expand our knowledge about the role of NhhA in meningococcal pathogenesis.