Hong Sjölinder

Hong Sjölinder

Euthyroid sick syndrome characterized by reduced levels of thyroid hormones is observed in patients with meningococcal shock. It has been found that the level of thyroid hormones reflects disease severity and is predictive for mortality. We investigate (1) the impact of thyroid hormone signaling pathway on host defense during meningococcal infection; (2) the role of bacterial virulence factors in host-pathogen interaction.

Role of the thyroid hormone signaling pathway in immune regulation during meningococcal sepsis

Pathogens, via their microbial-associated molecular patterns, trigger sequential intracellular events in both the immune system and the neuro-endocrine system.

Identification and characterization of novel bacterial virulence factors

By combining a mouse disease model with in vivo imaging we have characterized the dynamics of bacterial growth during meningococcal sepsis (Sjölinder et al. 2007 PLoS ONE).

Study of the meningococcal outer membrane protein NhhA and its role in host-pathogen interaction

On the surface of the bacterial membrane are several factors present that are expressed by the bacteria to facilitate bacterial movement or to mediate attachment to cells of the host organism.

Contact

Hong Sjölinder, Associate Professor


E-mail: hong.sjolinder@gmt.su.se

Tel: +46-8-16 2915
 

 

Visiting address

 Svante Arrhenius väg 20C, E445


Department of Genetics, Microbiology and Toxicology (GMT)


Stockholms Universitet


106 91 Stockholm

Group members