Elisabeth Haggård

Elisabeth Haggård

Bacterial viruses or phages for short, constitute the most abundant biological entities on Earth, the estimated population size is 10000000000000000000000000000000 particles. We are studying two aspects of the temperate P2-like phages, the molecular switch that controls the two life modes in can enter, and the capacity of their integrases to perform directed gene insertions into human genomes for safe gene therapy.

A molecular genetic switch.

Molecular genetic switches control alternative gene expression pathways and are important for various developmental schemes in prokaryotes as well as in eukaryote systems. We are interested to elucidate the mechanisms behind the regulation of a molecular switch that controls the life modes of a temperate phage.

Development of P2 integrase as a tool for site-specific gene insertions into unmodified human chromo

In contrast to general recombination, site-specific recombination does not require extensive regions of homology. The process is mediated by specific recombination enzymes that recognizes specific nucleotide sequences in the DNA targets, and is therefore limited to specific sites in the DNA. This can possibly be utilized as a tool to make directed insertions into the human genome for safe gene therapy.



Elisabeth Haggård, Professor
e-mail: elisabeth.haggard@gmt.su.se
Telephone: +46-8-16 3108
Fax:+46-8-16 4315

Visiting address
Svante Arrhenius väg 20C floor 5

Postal address
Department of Genetics, Microbiology and Toxicology
Stockholms Universitet
106 91 Stockholm

Group members