Ann-Beth Jonsson

Ann-Beth Jonsson

We study molecular mechanisms of the interaction and cross-talk between pathogenic bacteria and human target cells. Pathogenic bacteria use intricate strategies to exploit the host environment, such as induction of signal transduction pathways upon attachment to host epithelial cells, extensive antigenic variation of surface components, and interaction with regulators of complement activation. We aim to characterize how bacteria manipulate the host defence mechanisms to survive within the host and cause disease. Bacterial modulation of host cells during long-term infections can lead to cell damages and cancer. A better understanding of bacterial pathogenesis is a prerequisite for generation of novel therapies and vaccines against bacterial infection, which is urgently needed in the increasing occurrence of antibiotic resistance.

Bacterial virulence factors during sepsis

Acute meningococcal sepsis is a rapid and life-threatening disease with overwhelming inflammatory response and high mortality.

Cancer and Helicobacter pylori

Microbial pathogens have developed a variety of strategies to manipulate host cell function.

Pilus-mediated motility

Type IV pili (fimbriae) are long hair-like structures that mediates initial attachment of bacteria to host cells.

Bacterial infection and innate immunity

Antimicrobial peptides and the composition of the normal flora are two important factors in the immediate defence against invading pathogens.

Contact

Ann-beth porträtt

Ann-Beth Jonsson, Professor
e-mail: ann-beth.jonsson@gmt.su.se
Telephone: +46-8-16 4154
Fax:+46-8-16 4315

Visiting address
Svante Arrhenius väg 20C floor 5, room 451

Postal address
Department of Genetics, Microbiology and Toxicology
Stockholms Universitet
106 91 Stockholm

Group members